Download Advanced Bioactive Compounds Countering the Effects of by M. A. Christine Pratt (auth.), Grant N. Pierce, Volodymyr I. PDF

By M. A. Christine Pratt (auth.), Grant N. Pierce, Volodymyr I. Mizin, Alexander Omelchenko (eds.)

The likelihood for publicity to destructive radiation, poisonous chemical compounds within the surroundings and opposed organic brokers has elevated exponentially this day. The extra widespread and quicker go back and forth that we event at the present time additionally escalates the danger of contraction and transmission of probably lethal infections. This has created a really genuine and escalating possibility for accidents and deaths. this is often accentuated within the army and clinical employees that's extra usually uncovered to radiological, chemical, and organic brokers of their common operating surroundings. knowing the mechanisms wherein those poisonous brokers inflict harm to bodies is vital to organize us for those demanding situations. a lot of the wear is inflicted during the iteration of unfastened radicals and non-radical oxidants which then act via oxidative mechanisms to damage the physique. This quantity will talk about the wear and tear as a result of those radiological, chemical, and organic environmental stressors, the mechanisms by which the wear can ensue and the radical thoughts that may be used to minimize the damage inflicted via those poisonous compounds. utilizing uncomplicated and medical examine methods, the contents of this booklet speak about new principles for the advance of bioactive items and environmental ways to minimize or negate the organic harm inflicted through those noxious compounds.

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Extra info for Advanced Bioactive Compounds Countering the Effects of Radiological, Chemical and Biological Agents: Strategies to Counter Biological Damage

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Ehrlich JS, Brand M, Uder M et al (2011) Effect of proprietary combination of antioxidants/ glutathione-elevating agents on X-ray induced DNA double-strand breaks. Presented at the annual meeting of Society of Cardiovascular Computed Tomography, Denver, Colorado, USA 2011 2 Antioxidants as a Bio-shield Against Radiological Weapons 27 15. Ghosh SP, Kulkarni S, Hieber K et al (2009) γ-Tocotrienol, a tocol antioxidant, as a potent radioprotector. Int J Radiat Biol 85:598–606 16. Guan J, Stewart J, Ware JH et al (2006) Effects of dietary supplements on the space radiationinduced reduction in total antioxidant status in CBA mice.

It includes both radioprotective agents (prevention of damage) and radiation mitigating agents (treatment of damage). An ideal Bio-Shield must satisfy the following three criteria before it can be recommended to humans for reducing radiation injury: (1) chemicals or biologics should prevent and/or mitigate radiation damage in the laboratory experiments (cell culture and animals models) when administered before and/or after irradiation; (2) they should show at least some evidence that they can prevent or mitigate radiation damage in humans; (3) they at radioprotective or radiation mitigating doses must be safe in human when administered on a short- and longterm basis.

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