By D. Virgil Alfaro III MD, Peter E. Liggett MD, William F. Mieler MD, Hugo Quiroz-Mercado MD, Rama D. Jager MD MBA FACS, Yasuo Tano MD
A popular staff of retina surgeons provides promising new advancements in age-related macular degeneration, with emphasis at the most vital advances some time past 5 years. content material addresses all points of administration, together with anatomy, body structure, and pathophysiology; imaging of the macula in age-related macular degeneration; prevention measures and therapy; therapy; and destiny instructions. Abundantly illustrated and fantastically geared up, this ebook serves as a good reference and textbook.
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Additional info for Age-related macular degeneration : a comprehensive textbook
Graefes Arch Clin Exp Ophthalmol. 1993;231:470-475. 48. Soubrane G, Cohen SY, Delayre T, et al. Basic fibroblast growth factor experimentally induced choroidal angiogenesis in the minipig. Curr Eye Res. 1994;13:183-195. 78. Ambati J, Anand A, Fernandez S, et al. An animal model of age-related macular degeneration in senescent Ccl-1- or Ccr-2- deficient mice. Nat Med. 2003;9:1,390-1,397. 49. Saito Y, Kitano S, Furukawa H, et al. Experimental subretinal neovascularization. ARVO abstracts. Invest Ophthalmol Vis Sci.
24 occurs in older individuals who are unlikely to have parents or grandparents alive for comparative testing. Mutation of the Stargardt disease gene (ABCR) was found by Allikmets et al. (22) to be associated with ARMD (in particular the non-neovascular subtype), but this same association was not found by others (23,24). The APOE-ε4 allele has been found to be associated with a decreased risk, and the ε2 allele was associated with a slight increase in risk for ARMD (25,26). This association was not found by others, however (27,28).
This process probably came about secondary to massive apoptosis. Although hyperplastic scarring, remodeling, and apoptosis are common events in a wound healing response, they are not expected as an angiogenic response to simple ischemia. This suggests that there are other factors in addition to, or other than, simple ischemia. OXIDATIVE STRESS Although light-induced free radical oxidation in the photoreceptors has been known for almost 30 years, the full realization of the effects of oxidative damage is still being elucidated.