By L. Robert, T. Fulop, T. Fulop
Getting older encouraged quite a few theories attempting to rationalize the getting older method universal to all dwelling beings. during this ebook an important environmental and intrinsic mechanisms enthusiastic about the getting older procedure and in its pathological outcomes are reviewed. moreover theoretical and experimental facts of an important theoretical components according to Darwinian evolution, mobile getting older, position of cellphone membranes, unfastened radicals and oxidative procedures, receptor-mediated reactions, the extracellular matrix and immune features in addition to an important environmental and intrinsic mechanisms fascinated by the getting older approach and in its pathological outcomes are mentioned. those displays of theories and comparable experimental evidence provide an international evaluation of latest thoughts of the biology of the getting older procedure and are of crucial analyzing not just for experts during this box but in addition for practitioners of medical, clinical, social and experimental sciences.
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Extra resources for Aging: Facts and Theories
DNA synthesis is almost conﬁned to the basal layer and declines with age, with an enlargement of the nuclei and nucleoli of the basal cells. In humans, the number of parietal cells in the gastric mucosa tends to increase and that of mucous cells is reduced during normal aging . Since the mucus protects from acid secretion, the ﬁndings can explain an increased susceptibility of the gastric mucosa to damage in the elderly. The permanent restructuring that occurs in bone is the result of the continuous shift that takes place in the balance between the activity of osteoblasts and osteoclasts leading to a functionally deﬁcient architecture.
5–1 kb shorter than females in every tissue examined. The data suggested that telomere lengths may decrease due to factors other than the end replication problem during cell division . Chicken telomeres resemble human telomeres in length, but the distribution of telomerase activity is present in the germ line as well as in a wide variety of 30 Macieira-Coelho Robert L, Fulop T (eds): Aging: Facts and Theories. Interdiscipl Top Gerontol. 1159/000358898 somatic tissues as in mice . It is well known that chicken ﬁbroblasts have a ﬁnite proliferation span and contrary to mice exhibit extremely low rates of spontaneous immortalization.
The kinetics of cell proliferative aging concluded from these works are illustrated in ﬁgure 1. Other experiments attempting to identify the loss of the division potential of ﬁbroblasts in vitro claimed that at each doubling of the cell population there is production of nondividing cells, which increase exponentially [12, 13]. These authors did not realize that their experiments based on cloning of cells and on radioactive thymidine incorporation at low cell densities measured only the fraction of cells capable of initiating rapidly the division cycle.