Download Aging Mechanisms: Longevity, Metabolism, and Brain Aging by Nozomu Mori, Inhee Mook-Jung PDF

By Nozomu Mori, Inhee Mook-Jung

This e-book brings jointly the main updated info on contemporary examine result of top laboratories on getting older technological know-how in East Asia, rather in Japan, Korea, and Hong Kong. beginning with a finished evaluation of assorted hypotheses on organic mechanisms of getting older by way of Dr. Sataro Goto, every one bankruptcy covers large features of the newest findings in aging-related subject matters: centenarian reports and genome research of progeria, metabolic biochemistry and neurobiology, toughness controls in yeast and nematodes, oxidative rigidity and calorie restrict, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s ailments, with extra power healing techniques to those age-related neurodegenerative ailments. additionally integrated, partially, is a precis and the results of a systematic dialogue discussion board known as the Asian getting older center for sturdiness (AACL) that has been held each year alternating among Japan and Korea over the past decade. This e-book can function an invaluable source for locating acceptable collaborators within the parts it covers. the objective readership is made from graduate scholars and researchers at universities, scientific and/or life-science faculties, and biomedical and pharmaceutical institutes.

Why does getting older exist? How can we age? How is each one organism’s lifespan made up our minds? those are basic questions within the box. We can be nonetheless faraway from attaining an entire view of getting older mechanisms, yet this booklet, Aging Mechanisms, bargains an exceptional chance to familiarize yourself with the main up-to-date development within the biomedical study of getting older in Japan and Korea, the 2 major countries for human longevity.

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Methods Enzymol 186:464–478 Lindop PJ, Rotblat J (1961) Shortening of life and causes of death in mice exposed to a single whole-body dose of radiation. Nature 189:645–648 Ljungquist B, Berg S, Lanke J, McClearn GE, Pedersen NL (1998) The effect of genetic factors for longevity: a comparison of identical and fraternal twins in the Swedish Twin Registry. J Gerontol A Biol Sci Med Sci 53:M441–M446 Logan A, Shabalina IG, Prime TA, Rogatti S, Kalinovich AV, Hartley RC et al (2014) In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice.

Proc Natl Acad Sci U S A 45:30–45 Takahashi R, Goto S (1988) Fidelity of aminoacylation by rat-liver tyrosyl-tRNA synthetase. Effect of age. Eur J Biochem 178:381–386 Takahashi R, Goto S (1990) Alteration of aminoacyl-tRNA synthetase with age: heat-labilization of the enzyme by oxidative damage. Arch Biochem Biophys 277:228–233 Takalo M, Salminen A, Soininen H, Hiltunen M, Haapasalo A (2013) Protein aggregation and degradation mechanisms in neurodegenerative diseases. Am J Neurodegener Dis 2:1–14 Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE et al (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase.

Free Radic Biol Med 44:126–131 Goto S, Nakamura A (1997) Age-associated, oxidatively modified proteins: a critical evaluation. Age (Omaha) 20:81–89 Goto S, Rada´k Z (2009) Hormetic effects of reactive oxygen species by exercise: a view from animal studies for successful aging in human. Dose Response 8:68–72 Goto S, Takahashi R, Kumiyama A, Rada´k Z, Hayashi T, Takenouchi M et al (2001) Implications of protein degradation in aging. Ann N Y Acad Sci 928:54–64 24 S. Goto Grasso M, Piscopo P, Confaloni A, Denti MA (2014) Circulating miRNAs as biomarkers for neurodegenerative disorders.

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