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By Feinsilver P., Schott R.

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This key relationship of medical education and science to other scientific fields can best be strengthened and advanced by bringing the Medical School into the closest possible physical and intellectual relationship to the whole University. 1). 2). In addition to the “hopeless jumble” of the medical school and Lane Hospital, the former’s financial woes were growing worse; it had been losing four hundred thousand dollars annually by 1950. 1. Integration of the medical school and the university at Stanford.

The establishment of the Stanford Biochemistry Department, chaired by the Nobel laureate Kornberg, exemplified the university’s commitment to a new vision for biomedicine. The importation of a strong group of scientists in biochemistry and molecular biology to the Stanford Medical School was a key part of its ambitious effort to establish a center for biomedical and clinical research. In July 1953, Stanford president John E. Wallace Sterling, along with members of the board of trustees, had reached a conclusion that the medical school should be an integral part of the university, both geographically and intellectually.

Cohn’s, Hogness’s, and Kaiser’s postdoctoral work at the Pasteur Institute, as well as Monod’s and Jacob’s frequent interactions with Kornberg’s research group, brought a new perspective, which began to weld the connection between biochemistry and genetics during the 1950s and early 1960s, contributing to the development of molecular genetics. 69 More importantly, the biochemists shared a repertoire of enzymatic and genetic-analysis techniques that enabled them to decipher the biochemical pathways of nucleic acids, especially their roles in the production of proteins; gene expression and regulation— how nucleic acids embody genetic information and how they express and regulate their genetic information inside the cell— emerged as research subjects of intense scientific interest among both biochemists and molecular biologists.

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