By Lodovico Balducci, Martine Extermann
Biological foundation of Geriatric Oncology highlights examine concerns which are particular to geriatric oncology within the box of carcinogenesis and melanoma prevention and therapy, in response to the biologic interactions of melanoma and age. It illustrates the good thing about the foundations of geriatrics within the administration of melanoma within the older individual.
This quantity presents a body of reference for practicioners of any specialties considering the administration of older sufferers and for oncologists all for the administration of melanoma of older participants. it's a resource for simple and scientific scientists exploring the interactions and rising details of melanoma and aging.
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Additional info for Biological Basis of Geriatric Oncology
Thus, stimulation of uptake of glucose in tissues by biguanides inhibits lipogenesis and activates oxidation of FFA 149. It was shown also that in vivo biguanides inhibits an appetite 150,151 and serum levels of leptin and IGF-1 152. It was suggested that biguanides regulate energy balance of the organism at the fat tissue level 153. In general, results of bioguanides effects seem very similar to those of calorie restriction. BIOLOGICAL INTERACTIONS 41 42 V. ANISIMOV 8. CONCLUSION The incidence of cancer increases with age in humans and in laboratory animals alike, but patterns of age-related distribution of tumors is different for different tissues and different tumors.
BIOLOGICAL INTERACTIONS 21 Figure 2. Integral scheme of carcinogenesis a minimum of one intermediate stage). Secondly, passage from one stage to another is a stochastic event, the rate of which depends on the dose of a carcinogen that affects the cell. Finally, all cells at any stage of carcinogenesis may enter the next stage independently of each other. According to this model, the tumor develops only if at least one cell goes through all the necessary stages, and the clonal growth of this cell causes clinical cancer, as a critical volume of neoplastic cells accumulates.
Two main pathways the extracellular-signal related kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase (PI3K)-Akt pathway – were downregulated in mice. The extension of longevity was observed in fat-specific insulin receptor knockout (FIRKO) mice 114,115. These animals have reduced fat mass and were protected against age-related obesity and its subsequent metabolic abnormalities including deterioration in glucose tolerance, although their food intake was normal.