By Pascal Kintz, Pierre Marquet
In Buprenorphine remedy of Opiate dependancy, engaging physicians and toxicologists summarize and assessment their reports with 5 years of extensive buprenorphine remedy. They disguise all elements of its use, together with the pharmacology, stipulations of supply, dangers from use with different psychoactive medicinal drugs, toxicology and comparable deaths, in addition to its checking out in blood, urine, tissue, and hair. particular realization is given to evaluating the long term care of opiate-dependent sufferers utilizing high-dose buprenorphine vs methadone, and to explaining the diversities in therapy, management, and supply. The authors additionally describe how buprenorphine is at present prescribed and monitored in France and Australia, and evaluate the entire most recent advances in analytical recommendations for the selection of buprenorphine and its metabolites in organic fluids and tissues.
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Extra resources for Buprenorphine Therapy of Opiate Addiction (Forensic Science and Medicine)
Novel routes of opioid administration: part 1-sublingual and buccal. Primary Care Cancer 1989; January:55–6. 6. Bullingham RES, Dwyer D, Allen MC, Moore RA, McQuay HJ. Sublingual buprenorphine used postoperatively: clinical observations and preliminary pharmacokinetic analysis. Br J Clin Pharmacol 1981;12:117–22. 7. Bullingham RES, McQuay HJ, Porter EJB, Allen MC, Moore RA. Sublingual buprenorphine used postoperatively: ten hour plasma drug concentration analysis. Br J Clin Pharmacol 1982;13:665–73.
Over the course of more than 20 yr of clinical studies with buprenorphine, the tendency is for increasingly higher doses to be used. However, referring to such doses as “high” or “low” is a matter of relative comparison. A final point regarding the use of the term high-dose buprenorphine should be noted. Referring to a dose as low or high can suggest that the dose is ineffective (low) or excessive (high). In this respect, referring to high and low doses should be avoided. In the treatment of opioid dependence, what is necessary is the effective dose—the dose that produces the best outcomes for the patient, with minimal adverse effects.
MJA 1984;142:425–6. 31. Lewis JW. Buprenorphine. Drug Alcohol Depend 1985;14:363–72. 32. Tebbett IR. Analysis of buprenorphine by high-performance liquid chromatography. J Chromatogr 1985;347:411–3. 33. Vanacker B, Vandermeersch E, Tomassen J. Comparison of intramuscular buprenorphine and a buprenorphine/naloxone combination in the treatment of postoperative pain. Curr Med Res Opin 1986;10:139–44. 34. Preston KL, Bigelow GE, Liebson IA. Buprenorphine and naloxone alone and in combination in opioid-dependent humans.