By Cedrik Michael Britten, Sebastian Kreiter, Mustafa Diken, Hans-Georg Rammensee
This ebook presents a entire replace at the cutting-edge in melanoma immunology, which has speedily developed from a box of medical examine into a longtime self-discipline of oncology. the foremost contemporary advancements in immuno-oncology are all coated, from the ever-changing immunological and regulatory frameworks to the main promising healing ideas. issues comprise blend treatments and customized medication, in addition to identity of biomarkers to steer the scientific improvement of latest ways and to pinpoint the optimum remedy for every sufferer. The booklet recognizes the continued dynamic nature of the sphere as mirrored within the improvement of next-generation immunotherapies which are already in scientific testing.
Cancer Immunotherapy Meets Oncology is devoted to the lifetime achievements of Christoph Huber, founder and chair of the organization for melanoma Immunotherapy (CIMT). it's also a tribute to these researchers and clinicians who're striving to improve novel diagnostics and adapted immunotherapies for the advantage of melanoma patients.
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Additional resources for Cancer Immunotherapy Meets Oncology: In Honor of Christoph Huber
M. Britten et al. 1007/978-3-319-05104-8_5, © Springer International Publishing Switzerland 2014 37 38 relieve T cells from immunosuppressive elements (regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), M2 macrophages) and/or to stimulate tumor-rejecting innate immune cells (M1 macrophages, dendritic cells (DC)) (Gabrilovich et al. 2012; Rakhmilevich et al. 2012; Galluzzi et al. 2012) in order to change the tumor microenvironment. In addition, these immune-activating strategies may be combined with standard chemo(radio)therapy to reduce the tumor load.
G. Vaccines and immunmodulatory compounds) Immune response Tumor response Patient survival Classical Therapies in Oncology (surgery, irradiation, chemotheraphy, antibodies binding to tumour surface antigens) Fig. 1 Classical treatments in oncology versus vaccines and immunomodulatory compounds. Whereas all “classical” therapies in oncology hit the tumor, cancer immunotherapies hit the immune system. M. Britten et al. 34 designs (Britten et al. 2012) and clinical endpoints (Hoos et al. 2010; Wolchok et al.
M. Britten et al. capacity of dendritic cells can be considered as potency assays. In cases where the direct measure of potency is not possible or too laborious for routine analyses, surrogates for potency can be used, provided that a correlation between the surrogate and the real biological activity has been demonstrated. Surrogates may comprise expression of cell surface markers or secretion of factors. The reason why such specific guidance for cancer vaccines was published by EMA is that some cancer vaccines belong to the class of somatic cell therapies.