By Edward D. Zanders (auth.), Edward D. Zanders (eds.)
Chemical genomics know-how has been progressively enhancing, offering new organic probes and medicine, and the categorical use of the time period ‘chemical proteomics’ has elevated with it, as proteins have regularly been on the center of this expertise. In Chemical Genomics and Proteomics: reports and Protocols, specialists within the box current up to date stories of the chemistry of small molecules and their interplay with protein pursuits in addition to specific protocols that conceal sorts of ligands, carbohydrates, and lipids. for instance, the new release in their protein goals and techniques for measuring their interactions is roofed. Written within the hugely profitable Methods in Molecular Biology™ sequence layout, method chapters contain introductions to their respective subject matters, lists of the mandatory fabrics and reagents, step by step, effortlessly reproducible laboratory protocols, and tips about troubleshooting and warding off recognized pitfalls.
Thorough and recent, Chemical Genomics and Proteomics: reports and Protocols goals to supply thought to those that desire to use chemical genomics and proteomics of their paintings and improve this younger box into complete adulthood throughout the incorporation of the hot organic and chemical applied sciences starting to emerge here.
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Additional resources for Chemical Genomics and Proteomics: Reviews and Protocols
Lipinski CA, Lombardo F, Dominy BW et al (1997) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 23:3–25 6. Putta S, Beroza P (2007) Shape of things: computer modelling of molecular shape in drug discovery. Curr Top Med Chem 7:1514–1524 7. Nicholls A, McGaughey GB, Sheridan RP et al (2010) Molecular Shape and Medicinal Chemistry: A Perspective. J Med Chem 53:3862–3886 8. Sauer WHB, Schwarz MK (2003) Molecular Shape Diversity of Combinatorial Libraries: A Prerequisite for Broad Bioactivity.
In silico design of small molecules in particular is a prerequisite for a drug discovery and development campaign, and plays a critical role in the success of the program. Here, we review the most important data sources for the discovery of new molecular entities, and discuss the key considerations and guidelines for virtual chemical library design. Edward D. ), Chemical Genomics and Proteomics: Reviews and Protocols, Methods in Molecular Biology, vol. H. C. Tong 2. Data Sources Accessibility to quality data is an important ﬁrst step in the in silico design of small molecules.
Putta S, Beroza P (2007) Shape of things: computer modelling of molecular shape in drug discovery. Curr Top Med Chem 7:1514–1524 7. Nicholls A, McGaughey GB, Sheridan RP et al (2010) Molecular Shape and Medicinal Chemistry: A Perspective. J Med Chem 53:3862–3886 8. Sauer WHB, Schwarz MK (2003) Molecular Shape Diversity of Combinatorial Libraries: A Prerequisite for Broad Bioactivity. J Chem Inf Comput Sci 43:987–1003 9. Lovering F, Bikker J, Humblet C (2009) Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success.