Download Dementia in Clinical Practice (Frontiers of Neurology and by P. Giannakopoulos, P.R. Hof, J. Bogousslavsky PDF

By P. Giannakopoulos, P.R. Hof, J. Bogousslavsky

This e-book summarizes the newest advances in neurobiology, diagnostic methods and therapeutics of the key dementing health problems reminiscent of Alzheimer’s ailment, frontotemporal dementia, Lewy physique disorder, and vascular dementia. In a succinct, functional and entire demeanour, it presents an up to date view of the problems prone to be encountered in an everyday perform. each one part is targeted on a tremendous kind of dementia and is prepared following an analogous scheme reviewing the pathophysiology of the affliction, its diagnostic demanding situations, its attribute neuroimaging positive aspects, healing interventions and sufferer administration concerns. keeping off an overspecialized process, the e-book bridges the distance among medical perform, complex imaging, contemporary therapeutics and easy sciences. therefore, it serves as a good advisor for psychological future health pros operating within the box of dementia in addition to basic care physicians and scholars.

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Extra resources for Dementia in Clinical Practice (Frontiers of Neurology and Neuroscience)

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18 Dubois B, Albert M: Amnestic MCI or prodromal Alzheimer’s disease? Lancet Neurol 2004;3:246– 248. 19 Portet F, Ousset PJ, Visser PJ, Frisoni GB, Nobili F, Scheltens P, Vellas B, Touchon J, the MCI Working Group of the European Consortium of Alzheimer’s disease (EADC): Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium of Alzheimer’s Disease. J Neurol Neurosurg Psychiatry 2006;77:714–718.

Functional MRI and PET activation studies have not yet proved their utility in the diagnosis of MCI. Indeed, these techniques have inherent difficulties limiting their realization and the interpretation of the data. , patient lying still within an imaging device, control of actual engagement in the task). The other important limitation concerns the resolution of the signal amplitude. For example, the increase of oxyhemoglobin MRI signal in activated regions does not exceed 2 or 3%, rapidly showing ceiling effect.

The increase of cerebral blood flow is larger with PET activation studies, but the restriction in radiation dose limits task repetition and thus statistical power in each individual. Functional MRI studies of MCI patients using memory tasks have given variable results, some of them suggesting that there could be a compensatory increase of hippocampal activation, while others have shown decreased activation in this structure as well as in other regions implicated in AD [12, 13]. Activation studies are therefore useful for research purpose but are not used for clinical diagnosis of MCI or dementia.

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