By Frank Eisenhaber
This anthology provides severe experiences of equipment and high-impact functions in computational biology that bring about effects that non-bioinformaticians also needs to recognize to layout effective experimental study plans. gaining knowledge of Biomolecular Mechanisms with Computational Biology explores the technique of translating series strings into organic wisdom and considers exemplary groundbreaking effects comparable to unforeseen enzyme discoveries. This e-book additionally summarizes non-trivial theoretical predictions for regulatory and metabolic networks that experience got experimental affirmation.
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Extra resources for Discovering Biomolecular Mechanisms with Computational Biology (Molecular Biology Intelligence Unit)
Conservation of gene coregulation in prokaryotes and cukaryotes. Trends Biotechnol 2002; 20:407. 20. van Noort V, Snel B, Huynen MA. Predicting gene function by conserved cocxpression. Trends Genet 2003; 19:238-242. 2 1 . Stuart J M , Segal E, Koller D et al. A gene-coexpression network for global discovery of conserved genetic modules. Science 2003; 302:249-255. 22. Kelley BP, Sharan R, Karp RM et al. Conserved pathways within bacteria and yeast as revealed by global protein network alignment.
A conserved gene pair in prokaryotes. Trends Genet 2000; 16:11-14. 89. Coutts G, Thomas G, Blakey D et al. Membrane sequestration of the signal transduction protein GlnK by the ammonium transporter AmtB. E M B O J 2002; 21:536-545. 90. Bobik TA, Rasche M E . Identification of the human methylmalonyl-CoA racemase gene based on the analysis of prokaryotic gene arrangements. Implications for decoding the human genome. J Biol Chem 2 0 0 1 ; 276:37194-37198. 9 1 . Horswill AR, Escalante-Semerena JC.
Modelling The gap between the high number of known protein sequences and the only limited available 3-dimensional protein-structures is increasing rapidly. Molecular modelling techniques are valuable tools to fill this gap. ' In the field of cytochrome P450 research this technique is of high interest. Up to now more than 3700 cytochrom P450 (different named) sequences of different species are known, the determination of all these protein structures is a tedious work, because crystallization of some P450 enzymes, especially of the membrane-associated ones is 32 Discovering Biomolecular Mechanisms with Computational Biology Figure 2.