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By James R. Robertson

The exam of human hair within the forensic technological know-how environment is a hugely professional self-discipline. This quantity brings jointly for the 1st time all facets of hair exam. Contributions have come from a world panel of specialists.

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1991). , 1994) of AP1 and AP2 sites intimately associated with the binding sites for other regulatory factors, implicating the involvement of AP1 and AP2 factors in complex control mechanisms. A major problem in the investigation of hair keratin gene expression and the regulation of the process is the lack of an appropriate follicle cell line. At present, functional assays of potential control sequences of genes require the creation of transgenic mice, an expensive and time-consuming process.

The multilayering of the cuticle can cause it to be a large proportion of the overall diameter of the hairs, especially fine ones, and it therefore can make a large contribution to the hair stiffness. , personal communication). 1 Molecular Biology of Hair Growth Structural Proteins of the Hair Follicle and Their Genes The Complexity of Keratin Proteins and the Nomenclature Problem The understanding of the complexity of hair keratin proteins as large gene families has increased enormously in recent years through the advent of gene cloning.

7 A diagrammatic representation of the three dimensional arrangement of keratin IFs and the matrix of KAPs. The overall structure is sometimes referred to as the filament-matrix complex or the keratin complex. , 1993). The sulphur-rich matrix (KAP) proteins are amorphous and comprise about 40 per cent of the protein content of the cell. They have been referred to as ‘high-sulphur’ (HS) proteins and are characterized by a half-cystine content of about 27 mole per cent (Gillespie and Marshall, 1981).

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