By Reinhard B. Dettmeyer
This ebook, which mixes the beneficial properties of an atlas and a textbook, provides findings in forensic histology, immunohistochemistry, and cytology in line with microscopic investigations utilizing diversified stainings and various antibodies. The vital target is to supply practitioners with particular info and assistance on how microscopy may help to explain the reason for surprising and unforeseen dying. some of the subject matters could be of curiosity not just to forensic pathologists but additionally to normal pathologists, no matter if practitioners or researchers. Examples comprise the pathology of drug abuse, wound age choice, opposed drug reactions, histopathology of the surprising child dying syndrome, and age selection of myocardial infarction. either usual and weird findings are tested by means of a number of fine quality colour illustrations, and different key literature in forensic histology and immunohistochemistry is highlighted for every topic.
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Extra resources for Forensic Histopathology: Fundamentals and Perspectives
Thus, for example, the influence of fixation on the development of pulmonary alveoli has been investigated (Hausmann et al. 2004). In some cases, alternative fixing solutions are used: Bouin’s solution, Zamboni solution, “NoTox” (Meyer et al. 1996), pure alcohol, etc. In cases where an electron microscopic investigation is needed, glutaraldehyde is typically chosen as a fixative (3% solution for 24 h at 4°C, followed by phosphate buffer solution; additional fixation in 1% osmium acid, embedded in Epon).
Thus, this book aims to outline the basic principles and highlight the possibilities of diagnostics. It should be an aid in the decision-making process regarding type and extent of histological and immunohistochemical diagnosis, from sample selection to microscopic diagnosis. , basic fibroblast growth factor (bFGF) (Wang et al. 2009), P-selectin (Nogami et al. 2000), or hypoxia-inducible factor-1a (HIF-1a) (Zhu et al. 2008). In addition, it should be mentioned that advances in molecular biology have provided a procedure to investigate genetic bases of diseases that might be present with sudden death – so-called molecular pathology (Maeda et al.
1996), pure alcohol, etc. In cases where an electron microscopic investigation is needed, glutaraldehyde is typically chosen as a fixative (3% solution for 24 h at 4°C, followed by phosphate buffer solution; additional fixation in 1% osmium acid, embedded in Epon). It should be noted that fixative selection and dura tion can have a direct bearing on potential molecular genetic investigations (Kuhn and Krugmann 1995). B. 1 Frequently used conventional histological staining methods (selection) and sample questions that arise in forensic practice Staining Alcian blue Azan staining (azo carmine and aniline blue) Best’s carmine stain Presented structures Detection of acid mucopolysaccharides Examples from forensic practice Mucoid lakes, for example, in cases of idiopathic cystic Erdheim–Gsell medial necrosis and dissected aortic aneurysm Connective tissue staining (red): azo carmine Differentiates basophilic and chromophobe cells in stains cell nuclei, erythrocytes, fibrin, the hypophysis; loss of detectability, for example, in fibrinoid, acidophilic cytoplasm, epithelial the case of Sheehan syndrome hyalin; Aniline blue (blue): collagen fibers, fibrous hyalin, basophil cytoplasm, mucus Classified as a glycogen stain, but is not Glycogen detection in kidney distal tubular cells in specific; also stains mucus, fibrin, gastric the case of hyperglycemia (Armanni–Ebstein cells) glands, and mast cell granules Stains elastic fibers violet-black For example, elastic fibers in the aortic media Elastin staining according to Weigert Elastika van Gieson (EvG) Combined staining of collagen fibers (red) and elastic fibers according to Weigert (black and brown); cytoplasm, musculature, amyloid, fibrin, and fibrinoid (yellow) Iron stain (Prussian blue Stains trivalent iron, in particular hemosidreaction) erin; detection of iron deposits Fibrin staining according Blue: fibrin and bacteria to Weigert Red: cell nuclei; is not considered a specific fibrin stain Gomori’s stain Argyrophilic reticular fibers (silver) Grocott stain Haematoxylin–eosin (H&E) staining Congo red stain Kossa stain Luxol fast blue (LFB) Mallory’s stain Masson–Goldner stain May-Grünwald–Giemsa stain (MGG) Methylene blue Naphthol AS-D chloroacetate esterase stain (Moloney et al.