Download Killer Cell Dynamics: Mathematical and Computational by Dominik Wodarz PDF

By Dominik Wodarz

This publication experiences how mathematical and computational techniques may be worthwhile to aid us know how killer T-cell responses paintings to struggle viral infections. It additionally demonstrates, in a writing type that exemplifies the purpose, that such mathematical and computational ways are most precious whilst coupled with experimental paintings via interdisciplinary collaborations. Designed to be necessary to immunoligists and viroligists with no huge computational historical past, the publication covers a wide number of themes, together with either simple immunological questions and the appliance of those insights to the knowledge and remedy of pathogenic human ailments.

Show description

Read or Download Killer Cell Dynamics: Mathematical and Computational Approaches to Immunology PDF

Best applied books

Applied Scanning Probe Methods XIII: Biomimetics and Industrial Applications

The volumes XI, XII and XIII study the actual and technical origin for fresh growth in utilized scanning probe thoughts. the 1st quantity got here out in January 2004, the second one to fourth volumes in early 2006 and the 5th to 7th volumes in past due 2006. the sphere is progressing so quickly that there's a want for a collection of volumes each 12 to 18 months to catch most modern advancements.

Applied Bioinformatics: An Introduction

Harassed through cryptic machine courses, algorithms and formulae? during this e-book, somebody who can function a laptop, average software program and the web will discover ways to comprehend the organic foundation of bioinformatics of the lifestyles in addition to the resource and availability of bioinformatics software program how you can follow those instruments and interpret effects with self assurance.

Understanding and Modeling Förster-type Resonance Energy Transfer (FRET): FRET from Single Donor to Single Acceptor and Assemblies of Acceptors, Vol. 2

This short provides an entire learn of the generalized conception of Förster-type strength move in nanostructures with combined dimensionality. right here the purpose is to acquire a generalized thought of worry together with a accomplished set of analytical equations for all combos and configurations of nanostructures and deriving widely used expressions for the dimensionality concerned.

Extra info for Killer Cell Dynamics: Mathematical and Computational Approaches to Immunology

Sample text

Damped oscillations occur and the system approaches its steady state. Virus 30 2 Models of CTL Responses and Correlates of Virus Control load at the steady state is determined by two parameters. The rate of CTL proliferation, or CTL responsiveness c, and the death rate of CTL in the absence of antigenic stimulation b. e. lower value of b), the lower virus load. These are thought to be properties of a CTL memory response, and this concept is developed further in Chapter 3. Because the model is deterministic, virus load can never be reduced to zero.

If c(λ/a − d/β) < b, then the CTL response fails to become established. This is because the CTL responsiveness c is too low to ensure sustained CTL expansion. ] − , z ∗ = 0. K [ β On the other hand, if c(λ/a − d/β) > b, then a sustained CTL response develops, and the system converges to the following equilibrium. λc , dc + βb b y∗ = , c c(βλ − ad) − abβ ∗ . 3), virus first grows and stimulates the CTL. The CTL population expands and fights the virus population. Damped oscillations occur and the system approaches its steady state.

Recurring rounds of CTL proliferation will be induced, and the system will eventually converge towards a steady state. Virus load at this steady state determines the degree of virus control. The equilibrium expressions are given as follows. 5 Programmed CTL Proliferation 37 λ 1 −a , ∗ gy d/β + y ∗ gy ∗ m∗ z∗ = , p αy ∗ m∗ , m∗0 = r m∗i = 2i m∗0 , 1 < i < n − 1, m∗ = where g = (2n pα)/(γ + δ). Virus load is determined by a number of immunological factors. A high activation rate of memory CTL (high value of α) and a long life span of memory CTL in the absence of antigen (low value of ) contribute to low virus loads.

Download PDF sample

Rated 4.69 of 5 – based on 37 votes

About admin