By Michael Sand
Michael Sand supplies the reader an summary of present ideas in expression profiling of miRNAs and their maturation equipment within the dermis. This publication is a postdoctoral thesis on miRNAs in cutaneous malignant cancer and non-melanoma dermis melanoma with a spotlight at the miRNA processing equipment and miRNA expression profiling. The learn offered during this ebook was once played within the Dermatologic surgical procedure part on the division of Dermatology, Venereology and Allergology of the Ruhr-University Bochum, Germany and offers the reader an outline of present concepts in expression profiling of miRNAs and their maturation equipment within the skin.
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Extra resources for MicroRNAs in malignant tumors of the skin: First steps of tiny players in the skin to a new world of genomic medicine
188] In this study, miRNA expression profiles of primary cutaneous malignant melanomas (PCMM), cutaneous malignant melanoma metastases (CMMM), and benign melanocytic nevi (BMN) were created. To do so, biopsies were obtained intra-operatively during the excision of the tumors. After RNA extraction, miRNA expression profiles were created 48 3 Summary and discussion of this work using microarray and analyzed (Fig. 3-22, 3-23). To validate the data, a TaqMan RT-PCR of five significantly up-regulated and down-regulated miRNAs was performed (Fig.
Both the intranuclear miRNA-processing enzyme Drosha and the extranuclear microRNA-processing enzyme Dicer play pivotal roles in the maturation of miRNAs . Drosha is an RNase III endonuclease essential for the initial stages of miRNA biogenesis, cleaving pri-miRNAs (consisting of a hairpin stem, a terminal loop, and 5` and 3` single-stranded RNA extensions) to pre-miRNAs (60-70 nucleotide stem-loop structures). Once Exportin 5 transports premiRNAs to the cytoplasm, they are further cleaved by yet another RNase III enzyme called Dicer .
MiRNA expression profiles in melanoma SAND M, SKRYGAN M, SAND D, GEORGAS D, GAMBICHLER T, HAHN SA, ALTMEYER P, BECHARA FG (2013): Comparative microarray analysis of microRNA expression profiles in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases, and benign melanocytic nevi. Cell Tissue Res 351:85-98.  In this study, miRNA expression profiles of primary cutaneous malignant melanomas (PCMM), cutaneous malignant melanoma metastases (CMMM), and benign melanocytic nevi (BMN) were created.