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By Stephen Curran, John Wattis, Sean Lynch

The textual content examines the various remedies for melancholy within the aged. It indicates how the multi-disciplinary crew may perhaps impression the effectiveness of such remedies and discusses the sensible implications.

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Practical Management of Depression in Older People (Hodder Arnold Publication)

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Pharmacodynamic changes include increased receptor sensitivity and a reduction in total receptor numbers with increasing age. Changes in drug distribution, metabolism and excretion are the main pharmacokinetic factors involved. A shift in body composition with a relative reduction in total body water compared to fat alters the distribution of lipid-soluble drugs in particular. As a result, the halflife of many lipid-soluble psychotropic drugs is prolonged. Hepatic metabolism of psychotropic drugs is reduced because of decreased hepatic blood flow and slowed enzyme metabolism.

J. and Levy, R. (1996) Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed. Psychological Medicine, 26, 591-603. Burvill, P. P. (1991) The prognosis of depression in old age. British Journal of Psychiatry, 158, 64-71. Burvill, P. W. D. (1994) Predictors of increased mortality in elderly depressed patients. International Journal of Geriatric Psychiatry, 9, 219-227. G. (1990) The prognosis of depression in the elderly. Canadian Medical Association Journal, 143, 633-640.

Doraiswamy, P. , Benaur, M. et al. (1999) Magnetic resonance assessment of cerebral perfusion in depressed cardiac patients: preliminary findings. American Journal of Psychiatry, 156,1641-1643. E. and McHugh, P. R. (1975) Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatry Research, 12,189-198. J. (1976) The comparative frequency of depression in various adult age groups. Journal of Gerontology, 31, 283-292. , Leach, L. et al.

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