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H. Cheldelin, and R. W. Newburgh, Can. J. Zool. 34, 527 (1956). 138 L. L. Bieber, V. H. Cheldelin, and R. W. Newburgh, / . Biol. Chem. 238, 1262 (1963). 139a I. B. Fritz and P. Dupont, Federation Proc. 16, 42 (1957). 140 K. O. Donaldson and J. C. Keresztesy, / . Biol. Chem. 234, 3235 (1959). 141 J. C. Keresztesy and K. O. Donaldson, Biochem. Biophys. Res. Commun. 5, 286 (1961). 142 W. Sakami and I. Ukstins, J. Biol. Chem. 236, PC50 (1961). 143 A. R. Larrabee, S. Rosenthal, R. E. Cathou, and J. M.

34 6. CHOLINE and methionine methyls were found after the incubation of tissue preparations with 14C-labeled formate, 189 and in experiments in which the labeling of tissue choline in rats given heavy water on a diet lacking dietary labile methyl was greater than in those supplied choline or methionine. 190 Significantly, both folic acid and B 12 were components of the latter diet. i9i* 192 and by Stekol and Weiss 193 on the basis of rat growth on diets lacking obvious sources of labile methyl and containing homocystine and a suitable vitamin supplement.

Biophys. 54, 432 (1955). 13& E. Hodgson, V. H. Cheldelin, and R. W. Newburgh, Can. J. Zool. 34, 527 (1956). 138 L. L. Bieber, V. H. Cheldelin, and R. W. Newburgh, / . Biol. Chem. 238, 1262 (1963). 139a I. B. Fritz and P. Dupont, Federation Proc. 16, 42 (1957). 140 K. O. Donaldson and J. C. Keresztesy, / . Biol. Chem. 234, 3235 (1959). 141 J. C. Keresztesy and K. O. Donaldson, Biochem. Biophys. Res. Commun. 5, 286 (1961). 142 W. Sakami and I. Ukstins, J. Biol. Chem. 236, PC50 (1961). 143 A. R. Larrabee, S.

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