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By Daniel I. Simon, Campbell Rogers

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Extra info for Vascular Disease and Injury: Preclinical Research (Contemporary Cardiology)

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At this stage a second angioplasty 14 Part I / Acute Mechanical Injury and Vascular Repair Fig. 6. Photograph demonstrating the use of Kelly clamps to dissect bluntly through the subcutaneous space and pull the pump tube into the groin from the flank. H marks direction of head. T marks direction of tail. is performed, usually with fluoroscopic guidance to allow assessment of initial lesion location and severity. , Palo Alto, CA) are available in a variety of sizes which can deliver substances intravenously for up to 4 wk after placement.

Riess H, Hofling B, von Arnim T, Hiller E. Thromboxane receptor blockade versus cyclooxygenase inhibition: antiplatelet effects in patients. Thromb Res 1986; 42:235–245. 61. Schwartz L, Bourassa MG, Lesperance J, Aldridge HE, Kazim F, Salvatori VA, et al. Aspirin and dipyridamole in the prevention of restenosis after percutaneous transluminal coronary angioplasty. N Engl J Med 1988; 318:1714–1719. 62. Thornton MA, Gruentzig AR, Hollman J, King SB, 3rd, Douglas JS, Jr. Coumadin and aspirin in prevention of recurrence after transluminal coronary angioplasty: a randomized study.

2 mg/kg-d in patients would be impossible to achieve without severe side effects. In the pharmacology of drug testing across sppeies (including human patients), dosing is generally begun at comparable weight-adjusted (mg/kg) levels. It is possible, but unlikely, that the high doses used in rats and rabbits were comparable in efficacy to the doses used in the clinical human trials. The normal coronary artery of a young rat, rabbit, or pig differs markedly from the atherosclerotic coronary artery of an older human patient.

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